首页> 外国专利> CONFORMATIONALLY RESTRICTED 4-SUBSTITUTED-2,6-DIMETHYLFURO2,3-dPYRIMIDINES AS ANTITUMOR AGENTS

CONFORMATIONALLY RESTRICTED 4-SUBSTITUTED-2,6-DIMETHYLFURO2,3-dPYRIMIDINES AS ANTITUMOR AGENTS

机译：构象受限的4-取代-2,6-二甲基呋喃[2,3- d ]吡嘧啶作为抗老剂

展开▼

页面导航

摘要

著录项

相似文献

摘要

The present invention provides conformationally restricted 4-substituted 2,6-dimethylfuro[2,3-d]pyrimidine compounds and pharmaceutical compositions comprising these compounds. Preferably, the compounds exhibit dual inhibition of microtubule assembly and receptor tyrosine kinases. Methods of treating cancer comprising administering a therapeutically effective amount of at least one conformationally restricted 4-substituted 2,6-dimethylfuro[2,3-d]pyrimidine compound to a patient is disclosed. 展开▼

机译：本发明提供了构象受限的4-取代的2，6-二甲基呋喃并[2，3- d ]嘧啶化合物。展开▼

著录项

公开/公告号WO2016100495A1

专利类型

公开/公告日2016-06-23

原文格式PDF

申请/专利权人 DUQUESNE UNIVERSITY OF THE HOLY SPIRIT;
展开▼

申请/专利号WO2015US66062

发明设计人 GANGJEE ALEEM;
展开▼

申请日2015-12-16

分类号C07D491/048;A61K31/519;

国家 WO

入库时间 2022-08-21 14:17:25

相似文献

专利

外文文献

中文文献

1. N－(2,3－二氢－2,4－二甲基苯并呋喃－5－酰基)－N＇－叔丁基－N＇－(取代苯甲酰基)肼类杀虫剂的制备及应用 [P] . 中国专利： CN100567282C . 2009.12.09

2. N－(2,3－二氢－2,4－二甲基苯并呋喃－5－酰基)－N＇－叔丁基－N＇－(取代苯甲酰基)肼类杀虫剂的制备及应用 [P] . 中国专利： CN101190905A . 2008-06-04

3. Conformationally Restricted 4-Substituted-2,6-dimethylfuro2,3-dpyrimidines as Multi-targeted Receptor Tyrosine Kinase Inhibitors and Microtubule Targeting Antitumor Agents [P] . 美国专利： US2016176891A1 . 2016-06-23

机译：构象受限的4-取代的2,6-二甲基呋喃[2,3-d]嘧啶类化合物作为多靶点受体酪氨酸激酶抑制剂和靶向微管的抗肿瘤剂

4. CONFORMATIONALLY RESTRICTED 4-SUBSTITUTED-2,6-DIMETHYLFURO2,3-DPYRIMIDINES AS ANTITUMOR AGENTS [P] . CA2971606A1 . 2016-06-23

机译：构象受限的4-取代-2,6-二甲基呋喃[2,3-D]嘧啶类抗肿瘤剂

5. Conformationally restricted 4-substituted-2,6-dimethylfuro2,3-dpyrimidines as anti-tumor agents [P] . 美国专利： US10189853B2 . 2019-01-29

机译：构象受限的4-取代的2,6-二甲基呋喃[2,3-d]嘧啶类药物作为抗肿瘤剂

1. The design, synthesis and biological evaluation of conformationally restricted 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multi-targeted receptor tyrosine kinase and microtubule inhibitors as potential antitumor agents [J] . Zhang Xin, Raghavan Sudhir, Ihnat Michael, Bioorganic and medicinal chemistry . 2015,第10期

2. The design and discovery of water soluble 4-substituted-2,6-dimethylfuro[2, 3-d]pyrimidines as multitargeted receptor tyrosine kinase inhibitors and microtubule targeting antitumor agents [J] . ZhangX., RaghavanS., IhnatM., Bioorganic and medicinal chemistry . 2014,第14期

3. The design and discovery of water soluble 4-substituted-2,6-dimethylfuro[2, 3-d]pyrimidines as multitargeted receptor tyrosine kinase inhibitors and microtubule targeting antitumor agents [J] . ZhangX., RaghavanS., IhnatM., Bioorganic and medicinal chemistry . 2014,第14期

4. MEDICINAL MATERIALS FOR DIAGNOSING AND CURING CANCER (5): SUGAR DENDRITIC Gd-DTPA COMPLEX MRI CONTRAST AGENTS AND PHOSPHA SUGAR MULTIPLE TYPE MOLECULAR TARGETED ANTITUMOR AGENTS [C] . Makita R., Yamashita. M., Yamaoka M. International Carbohydrate Symposium . 2013

5. The therapeutic targeting of folate recptor alpha positive tumors via folate receptor-selective novel 5-and 6- substituted pyrrolo [2,3- d] pyrimidine antifolates. [D] . Mitchell-Ryan, Shermaine Kimberly. 2015

6. The Design Synthesis and Biological Evaluation of Conformationally Restricted 4-Substituted-26-dimethylfuro23-dpyrimidines as Multi-targeted Receptor Tyrosine Kinase and Microtubule Inhibitors as Potential Antitumor Agents [O] . Xin Zhang, Sudhir Raghavan, Michael Ihnat, -1

7. The design, synthesis and biological evaluation of conformationally restricted 4-substituted-2,6-dimethylfuro2,3-dpyrimidines as multi-targeted receptor tyrosine kinase and microtubule inhibitors as potential antitumor agents [O] . Xin Zhang, Sudhir Raghavan, Michael Ihnat, 2015

1. Computational Studies on the Ground State Tautomer,Hydrogen Conformations and Vibrational Spectroscopic Analysis of Antitumor Agents:3-Deazauracil and 6-Azauracil [J] . (C)a(g)r(i) (Ci)rak ,Nutettin K(o)r(o)zlü ,Yusuf Sert . 光谱学与光谱分析 . 2018,第004期

2. JJo, a Recombinant Dimer of Conformationally Restricted Peptide Elicits Protective Response against Group A Streptococcus (GAS) Isolates from a GAS-Endemic Region [J] . Raju Sunagar ,Vidiya Ramachandran ,Melina Georgousakis . 疫苗（英文） . 2011,第4期

3. Synthesis, Crystal Structure and Antitumor Activity of 4-(5-(2,6-Difluorophenyl)-1,3,4-o xadiazol-2-ylthio)-2-(trifluoromethyl)thieno 2,3-dpyrimidine [J] . SONG Xin-Jian ,LI Chen-Chen ,WANG Xu-Mei . 结构化学 . 2019,第008期

4. Synthesis, Characterization and iIn Vitro/iAntitumor Evaluation of New Pyrazolo3,4-dPyrimidine Derivatives [J] . Ahmed M. El-Morsy ,Mohamed S. El-Sayed ,Hamada S. Abulkhair . 药物化学期刊（英文） . 2017,第1期

5. Synthesis, Crystal Structure and Antitumor Activities of Ethyl5-methyl-4-morpholino-2-(3-Methyl-phenylamino)-furo2,3-dpyrimidine-6-carboxylate [J] . LI Yan ,TANG He-Xin ,GAO Hai-Tao . 结构化学 . 2013,第012期

6. N-(4-取代嘧啶-2-基)苄基磺酰脲和苯氧基磺酰脲在溶液中的构象变化和3D-QSAR研究 [C] . 马翼 ,李正名 ,姜林 . 第六届全国新农药创制学术交流会 . 2005

7. 具有生物活性的多取代-2-氨基嘧啶衍生物及其稠杂环化合物的研究（Ⅷ、Ⅸ）;Ⅷ：N'-（4,6-二取代嘧啶-2-基）-N-取代酰基硫脲的合成，晶体结构及除草活性;Ⅸ：5,7-二取代芳酰亚胺基-2H-1,2,4-噻二唑并[2,3-a]嘧啶的合成及除草活性 [A] . 王洁平 . 2003