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COMPETITIVE CONSUMPTION CARCINOGENESIS MICRORNAS LNCRNA AND ONCOLYTIC ADENOVIRUS, AND APPLICATION THEREOF

机译:竞争性消费致癌微RNA LNCRNA和溶瘤性腺病毒及其应用

摘要

Provided are an LncRNA and oncolytic adenovirus, and application thereof. The oncolytic adenovirus is used as a carrier to express the LncRNA, so as to express the LncRNA in a cancer cell; competitively binding a target gene of OncomiRs, and consuming the OncomiRs, thus protecting a cancer suppressor gene from interference and suppression of the OncomiRs, and achieving target intervention therapy of the cancer cell.
机译:提供了一种LncRNA和溶瘤腺病毒及其应用。溶瘤腺病毒被用作载体表达LncRNA,从而在癌细胞中表达LncRNA。通过竞争性结合OncomiRs的靶基因并消耗OncomiRs,从而保护癌抑制基因免受OncomiRs的干扰和抑制,从而实现癌细胞的靶标干预治疗。

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