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MICROFLUIDIC SYSTEM, MANUFACTURING METHOD THEREOF AND METHOD OF CELL ENCAPSULATION IN HYDROGEL

机译:微流控系统,其制造方法及其在胶囊中的细胞包封方法

摘要

The present invention relates to a technology of capsulating cells in a hydrogel and, more specifically, to a microfluidic device for allowing cells to be dispersed into single cells while passing through a fine column array zone and a focusing zone, and to be supported in a hydrogel, and to a method for manufacturing the microfluidic device, and a method for supporting cells in a hydrogel. When the method for supporting cells using the microfluidic device of the present invention is used, microorganism cells which are not in a conglomerated spherical shape can be dispersed by using a structure of a fine column array zone. In addition, the microorganism cells can be supported in a hydrogel drop in the form of a single cell, in a focusing zone, thereby solving problems of cellular aggregation caused by a polymer, and supporting the dispersed cells in a hydrogel in the form of a single cell.
机译:本发明涉及将细胞包封在水凝胶中的技术,更具体地,涉及一种微流体装置,其允许细胞在通过细柱阵列区和聚焦区时分散成单个细胞,并被支撑在水凝胶以及用于制造微流体装置的方法和在水凝胶中支撑细胞的方法。当使用使用本发明的微流体装置的细胞支持方法时,可以通过使用精细的列阵列区的结构来分散非聚集球形的微生物细胞。另外,微生物细胞可以以单个细胞的形式在聚焦区域中以水凝胶滴的形式被支撑,从而解决了由聚合物引起的细胞聚集的问题,并且以水凝胶的形式将分散的细胞支撑在水凝胶中。单细胞。

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