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1 Vectors and processes for expression of neuraminidase N1 of avian influenza virus in E. coli methods of using the same and agents for inhibiting activities of the neuraminidase

机译：1在大肠杆菌中表达禽流感病毒神经氨酸酶N1的载体和方法及其使用方法和抑制神经氨酸酶活性的试剂

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摘要

The present invention relates to a vector and a method for expressing neuraminidase N1 of Avian Influenza (AI) virus in Escherichia coli, a method for screening an activity inhibitor of neuraminidase N1 using the same, The present invention relates to a novel Nilaminidase N1 activity inhibitor screened by E. coli, which can express AI virus neuraminidase N1 in E. coli in a large amount rapidly, invitro ) AI virus Nilaminidase N1 Inhibitory agent candidate can be measured and evaluated to efficiently screen AI virus neuraminidase N1 inhibitor having excellent activity. As a result, AI virus neuraminidase N1 activity can be efficiently And 62 compounds that inhibit it.

机译：本发明涉及在大肠杆菌中表达禽流感（AI）病毒的神经氨酸酶N1的载体和方法，使用该载体和方法筛选神经氨酸酶N1的活性抑制剂的方法，本发明涉及新型的神经酰胺酶N1活性抑制剂。通过在大肠杆菌中快速表达大量AI病毒神经氨酸酶N1的大肠杆菌进行筛选，可以测定 in 体外）AI病毒Nilaminidase N1抑制剂候选物并进行了评估，以有效筛选具有出色活性的AI病毒神经氨酸酶N1抑制剂。结果，可以有效地抑制AI病毒神经氨酸酶N1的活性和抑制它的62种化合物。 展开▼

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公开/公告号KR101574490B1

专利类型

公开/公告日2015-12-07

原文格式PDF

申请/专利权人 전남대학교산학협력단;
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申请/专利号KR20150027358

发明设计人 김도만;김영민;김도원;훵충리;잉따우;빙상 브레통;
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申请日2015-02-26

分类号A61K31/132;C07K14/11;C12N15/09;C12N15/64;

国家 KR

入库时间 2022-08-21 14:15:30

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3. 1 Vectors and processes for expression of neuraminidase N1 of avian influenza virus in E. coli methods of using the same and agents for inhibiting activities of the neuraminidase [P] . 韩国专利： KR101568974B1 . 2015-11-13

机译： 1在大肠杆菌中表达禽流感病毒神经氨酸酶N1的载体和方法及其使用方法和抑制神经氨酸酶活性的试剂

4. Vectors and processes for expression of neuraminidase N1 of avian influenza virus in E. coli, methods of using the same, and agents for inhibiting activities of the neuraminidase [P] . 韩国专利： KR20150035886A . 2015-04-07

机译：在大肠杆菌中表达禽流感病毒的神经氨酸酶N1的载体和方法，其使用方法以及抑制神经氨酸酶活性的试剂

5. Vectors and processes for expression of neuraminidase N1 of avian influenza virus in E. coli, methods of using the same, and agents for inhibiting activities of the neuraminidase [P] . 韩国专利： KR20150035885A . 2015-04-07

机译：在大肠杆菌中表达禽流感病毒的神经氨酸酶N1的载体和方法，其使用方法以及抑制神经氨酸酶活性的试剂

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