Preparation method of nanocomplex with calcium ion and hydrophilic bisphosphonates and drug delivery systems using the same

摘要

The present invention relates to a method for preparing a nanocomposite using calcium ion and hydrophilic bisphosphonate, and a drug delivery system using the nanocomposite, and more particularly, to a method for preparing a nanocomposite using a calcium ion (Ca ²⁺ ) aqueous solution; And a hydrophilic bisphosphonate aqueous solution to prepare nanoparticles; And coating the prepared nanoparticles with branched polyethyleneimine (bPEI) or protamine sulfate (PS), and a nanocomposite prepared by the method. The present invention also provides a composition for treating osteoporosis, an anticancer composition or a drug delivery composition comprising the nanocomposite as an active ingredient.