PEPTIDE WITH ANTI-INFLAMMTORY ACTIVITY, OSTENOGENESIS, AND HAIR GROWTH ACTIVITY, AND USE OF SAME

摘要

Provided in the present invention is a peptide having anti-inflammatory and ostenogenic activities comprising an amino acid sequence selected from a group of first, second and third amino acid sequence listings. The peptide, comprising the amino acid sequence of first, second or third amino acid sequence listing, suppresses the expression of an inflammatory cytokine and propagation of inflammatory cells, thereby showing anti-inflammatory activity. The peptide increases the phosphorylation of PI3K, Smad1, Smad5 and Smad8 which is relevant to ostenogenesis, and the expressions of ALP, OPG, and BSP, thereby promoting the formation of bones as a result. The peptide, comprising the first or second amino acid sequence listing, promotes the propagation of umbilical vein endothelial cells, increases the phosphorylation of ERK, increases the expressions of PI3K, β-catenin, IFG-1 KGF, and Wnt3a, which are relevant to the growth of hair, and decreases the expression of DKK-1, which is relevant to hair loss, thereby preventing hair loss and promoting hair growth.;COPYRIGHT KIPO 2016