MICRONEEDLES WITH IMPROVED OPEN CHANNEL CROSS-SECTIONAL GEOMETRIES

摘要

In one aspect, the drug delivery device may comprise a micro-needle assembly in flow communication with the storage unit and a storage unit containing a liquid drug formulation. Fine needle assembly may comprise a plurality of micro-needles, each micro-needle defines an open channel for receiving the drug formulation. Open channel may have a hydraulic radius of about 0.1 to about 0.8 normalized range (hydraulic radius). Open channel is also a drug preparation of the fixed volume is that in receiving is the liquid-solid interface energy (liquid-to-solid interfacial energy) and the liquid-vapor surface energy (liquid-to-vapor interfacial energy) to take may be. In addition, the cross-sectional structure of the drug formulation and an open channel, as the length of a fixed volume of drug formulation increases in the open channel, the liquid-solid energy liquid-selected to greater than the steam energy and may be made ;