COMPOSITION FOR ANKYLOSING SPONDYLITIS RISK PREDICTION USING DNA COPY NUMBER VARIANTS AND USE THEREOF

摘要

The present invention relates to a method for predicting the onset risk of ankylosing spondylitis by using DNA copy number variants. The onset risk of ankylosing spondylitis can be effectively predicted by using a primer for detecting DNA copy number variants of the present invention. The sensitivity and specificity to the prediction can be enhanced by grafting measurement results of single nucleotide polymorphism (SNP). Therefore, more fundamental approaches are expected regarding the prevention and treatment of ankylosing spondylitis. The composition comprises a combination of genetic markers on chromosomes in a 1q32.2 position, a 2q31.2 position, a 6p21.32 position, a 13q13.1 position, and a 16p13.3 position. The method comprises the following steps: (a) performing a PCR; (b) sequencing the PCR product; and (c) determining whether a sample has DNA copy number variants from the sequencing results.