NEW MARKERS FOR SEVERE PROGRESSION OF IDIOPATHIC SCOLIOSIS AND USES THEREOF TO STRATIFY SCOLIOTIC PATIENTS AND PREDICT THE RISK OF DEVELOPING SCOLIOSIS

摘要

Methods are provided for stratifying individuals who are suffering from or at risk of development of juvenile idiopathic scoliosis (AIS) to a genuinely or clinically useful subclass. Stratification is based on PTP 占 expression and / or activity and / or PIPK1γ expression and / or activity of an individual. A method for predicting the risk of development of scoliosis based also on PTP 占 expression and / or activity and / or PIPK1γ expression and / or activity of an individual; And inhibitors of PIPK1 [gamma] tyrosine phosphorylation; An activator of PIPK1? Tyrosine dephosphorylation; And / or an effective amount of an inhibitor of PIPK1 gamma expression and / or activity is administered to a cell of an individual.