CD40 SIGNALLING INHIBITOR AND A FURTHER COMPOUND, WHEREIN THE FURTHER COMPOUND IS A BILE ACID, A BILE ACID DERIVATIVE, AN TGR5-RECEPTOR AGONIST, AN FXR AGONIST OR A COMBINATION THEREOF, FOR THE TREATMENT OF CHRONIC INFLAMMATION, AND THE PREVENTION OF GASTROINTESTINAL CANCER OR FIBROSIS

摘要

The present invention provides CD40 signaling inhibitors and additional compounds for the treatment of chronic inflammatory disease in a subject in need of treatment of chronic inflammatory disease, said additional compound being selected from the group consisting of bile acid, bile acid derivatives, TGR5-receptor agonists, FXR- . The present invention also provides CD40 signaling inhibitors and additional compounds for the prevention of cancer and / or fibrosis, wherein the additional compound is bile acid, a bile acid derivative, a TGR5-receptor agonist, an FXR-receptor agonist, or a combination thereof.