CONSTRUCTION OF CELLS EXPRESSING GENES OF DISEASES RELATED TO MITOCHONDRIAL PROTEIN UQCRB AND CONSTRUCTION OF EVALUATION METHOD ADJUSTING FUNCTIONS OF UQCRB USING SAME

摘要

The present invention relates to mitochondrial Ubiquinol-cytochrome c reductase binding protein (UQCRB) mutant cell strain expressing UQCRB mutant proteins. In the present invention, provided are an anticancer activity evaluation method, a vascularization inhibitory activity evaluation method, and a method for screening substances inhibiting activity of UQCRB as novel research methods of UQCRB activity evaluation using a novel mitochondrial UQCRB mutant cell strain. Particularly, the cell strain of the present invention is a novel cell strain having activity to induce cell proliferation and vascularization, and provides a method for screening substances inhibiting vascularization or anticancer substances through an inhibitory mechanism on UQCRB activity, thereby being useful to apply for developing medicine for vascularization, mitochondria-mediated diseases, and various cancers.;COPYRIGHT KIPO 2016