QUANTUM MOLECULAR SEQUENCING (QM-SEQ): IDENTIFICATION OF UNIQUE NANOELECTRONIC TUNNELING SPECTROSCOPY FINGERPRINTS FOR DNA, RNA, AND SINGLE NUCLEOTIDE MODIFICATIONS

摘要

natural and synthetic, and modified and make the unmodified DNA, RNA, PNA, DNA / RNA, and nucleotide sequencing to useful technique, method, apparatus, and compositions are disclosed. The disclosed techniques, a method, apparatus, and compositions using the nano-electronic quantum tunneling spectroscopy which can be referred to as the QM-Seq, it is useful to identify the various modifications, DNA / RNA damage, and the nucleotide structure. These methods and compositions are not charged, with a soft substrate, deformed, or scan the DNA / RNA / PNA unmodified, natural and synthetic, modified and modified for the deposition of single-stranded nucleotides and polynucleotides macromolecules under a nucleobase, and the same or similar conditions, for example, an electronic signature of the nucleobases of the unknown with respect to the database of the electronic fingerprint of the nucleobases are known, including the secondary / tertiary structure obtained when in the acidic environment nucleobase may include comparing. ;