METHOD FOR TOTAL SYNTHESIZING -PYRONE DERIVATIVES USING BY GOLD CATALYST AND -PYRONE DERIVATIVES HAVING CYTOTOXICITY AGAINST HUMAN CANCER CELL SYNTHESIZED THEREBY

摘要

The present invention relates to a method for total synthesis of an -pyrone derivative comprises preparing a -ketoester compound starting from butanol through the Witting olefin reaction, Swern oxidation reaction, Corey-Fuchs reaction and Claisen condensation, and subjecting the -ketoester compound to 6-endo-dig intramolecular cyclization using a gold catalyst to form an -pyrone ring and to carry out total synthesis of an -pyrone derivative. The -pyrone derivative obtained by the total synthesis method is (+)-violapyrone C having the same shape as the naturally occurring -pyrone derivative and has cytotoxicity against at least 10 human cancer cell lines, and thus can be useful as an anti-cancer agent.