TARGET GENES FOR ANTI-FUNGAL AGENT OF CRYPTOCOCCUS NEOFORMANS AND USE THEREOF

摘要

The present invention relates to target genes for an anti-fungal agent which adjust reaction to antimicrobial resistance, growth, mating, and external stress in Cryptococcus neoformans. According to the present invention, the target genes can effectively search an anti-fungal target material which enhances an antibacterial effect and a treatment effect of meningitis by detecting the level of expression of a novel transcription factor of the Cryptococcus neoformans stain. Moreover, the present invention provides a method of screening the target material which can have a synergistic effect when combined with existing antibacterial agents or agents for treatment of meningitis and a pharmaceutical composition having an antibacterial effect or a treatment effect of meningitis as the composition increases or inhibits the expression of novel transcription factors. In the present invention, by conducting a large-scale toxicity analysis using insect models and animal models, a number of transcription factors related to the virulence of Cryptococcus neoformans were identified, and the complex correlation between in vitro and in vivo phenotypic characteristics of homologous pathogens was determined.;COPYRIGHT KIPO 2016