PPARG PPARG Compounds that binding with PPARGPeroxisome Proliferator Activated Receptor-Gamma but not act as an agonist and pharmaceutical composition for diseases related with PPARG containing the same as an active ingredient

摘要

The present invention relates to a compound for inhibiting PPARG phosphorylation by CDK5 and a pharmaceutical composition for treating a PPARG-related disease containing the same as an active ingredient. The compound represented by the formula (1) or an optical isomer thereof according to the present invention has high affinity But does not act as an agonist and does not induce gene transcription and blocks CDK5, which is the cause of PPARG phosphorylation. Thus, adverse effects of conventional diabetes therapeutic agents do not occur and pharmacological properties are improved, , And has excellent therapeutic effect on PPARG-related diseases and can be usefully used as a pharmaceutical composition for the treatment of PPARG-related diseases.