ZINC SUPPLEMENTATION TO INCREASE RESPONSIVENESS TO METALLOPROTEASE THERAPY

摘要

The present invention provides methods and compositions for increasing the reactivity to therapeutic metalloproteases including increasing and / or maximizing reactivity and preventing botulinum and tetanus toxin resistance due to functional deficiency of zinc. Also provided is a method of replacing or supplementing zinc in a female subject, comprising administering a zinc supplement during the loading period and / or administering a phytase supplement with the zinc supplement. There is also provided a method of standardizing a botulinum toxin potency assay that provides greater confidence and safety in use of a product from different manufacturers.