Antibiotic peptide analogues with high activities against multidrug resistant bacteria and fungi and anti-inflammatory activities designed from Protaetiamycine and their uses

摘要

The present invention relates to a white spotted flower ( Protaetia 1 to 7, which reduce cytotoxicity while maintaining antimicrobial and anti-inflammatory activity based on an antimicrobial peptide designed based on a 9-residue sequence of the a-helix region of the proteatomicin isolated from the larvae of brevitarsis Seven species, their uses and mechanisms. The two novel antimicrobial peptides of the present invention exhibit excellent antimicrobial activity against resistant bacteria and acne bacteria, exhibit anti-inflammatory activity at the same time, and are free from cytotoxicity, so that they can be effectively used as antimicrobial agents, antifungal agents and the like which are safe for human body.