Peripheral blood stem cells primed with activated platelet supernatent having increased function of blood formation and its use

摘要

The present invention discloses a method for producing peripheral blood stem cells having improved angiogenesis through EPO or APS-priming, and uses thereof. Cells produced according to the method of the present invention induce angiogenesis and are useful in the treatment of various diseases requiring promotion of angiogenesis, such as ischemic diseases caused by muscle, brain, heart, kidney, or large intestine, Cerebral infarction, cardiac hypertrophy, hypochondroplasia, maladaptive heart failure, systolic heart failure, diastolic heart failure, hypertensive heart failure, arterial hypertension, cardiomyopathy, cerebral infarction, stroke, reperfusion injury, myocardial infarction, congestive heart failure, peripheral vascular occlusion, Phoban disease, pulmonary valve disease cardiovascular, or ischemic intestinal cardiovascular regeneration or recovery.