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Methods and appratus for high-throughput label-free cell assay

机译:高通量无标记细胞测定的方法和设备

摘要

the present invention is scanned by a broadband laser light source, the lower portion of the medium made of glass using a galvanometer mirror and the objective lens, using a spectrometer light coming back is reflected on the lower portion of the medium analyzing, imaging, but, spectrometer, the measured seupekteureomreul a light return is reflected at each interface forming interference medium glass, by measuring the phase at the interference seupekteureomreul Fourier transform measurement data for observing the structural change of the cell, high-power non- It relates to a cell analysis system markers. unlabeled cell analysis system of the present invention, for transmitting incident light from the broadband light source to a galvanometer mirror, and transmits the light incident from the galvanometer mirror as spectroscopy, optical fibers coupler; And provided with two mirrors, that follows the second rotation of the two mirrors, and passing the light input through the optical fiber coupler from a broadband light source to the objective lens, a transparent medium, the sample order, back through the transparent medium and the objective lens from the sample for emitting light to the optical coupler, the galvanometer mirror; But outputs the image to detect a spectrum of light incident from the optical fiber coupler, which, spectrometer output an image of the formed interference spectrum cause interference by the sample and the transparent medium; made including, the image of the interference spectrum, the objective lens doedoe through the light is reflected from the sample is incident to the transparent medium, characterized in that the image obtained by causing an interference by the boundary of the sample and the transparent medium. ;
机译:本发明由宽带激光源扫描,玻璃的下部介质用检流计镜和物镜,分光光度计返回的光反射在下部介质上进行分析,成像,但,光谱仪中,测得的seupekteureomreul在形成干涉介质玻璃的每个界面处反射回光,通过测量干涉seupekteureomreul傅立叶变换测量数据的相位以观察电池的结构变化,大功率非分析系统标记。本发明的未标记细胞分析系统,用于将来自宽带光源的入射光传输至检流计镜,并且将从检流计镜入射的光作为光谱,光纤耦合器进行传输。并设有两个反射镜,跟随两个反射镜的第二次旋转,并使通过光纤耦合器输入的光从宽带光源传输到物镜,透明介质,样品顺序,再通过透明介质和从样品发射光的物镜到光耦合器,检流计镜;但是输出图像以检测从光纤耦合器入射的光谱,光谱仪输出形成的干涉光谱的图像引起样品和透明介质的干涉。使得包括干涉光谱的图像,物镜通过光从样品反射而入射到透明介质上,其特征在于该图像是通过对样品和透明介质的边界造成干涉而获得的。 ;

著录项

  • 公开/公告号KR101602359B1

    专利类型

  • 公开/公告日2016-03-11

    原文格式PDF

  • 申请/专利权人 연세대학교 산학협력단;

    申请/专利号KR20150063002

  • 发明设计人 주철민;유수호;

    申请日2015-05-06

  • 分类号G01N21/25;G01N21/39;G01N33/483;

  • 国家 KR

  • 入库时间 2022-08-21 14:12:50

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