MEDICINAL COMPOSITION FOR TRANSDERMAL ABSORPTION MEDICINAL COMPOSITION STORING UNIT AND TRANSDERMAL ABSORPTION PREPARATION USING THE SAME

摘要

And to provide a sustained-release percutaneous absorption medicament and the like that can sustain the blood concentration of the morphine at an effective level for at least 48 hours. Wherein the transdermal absorption preparation is prepared by blending an effective ingredient selected from morphine or a salt thereof in an amount of a saturation solubility or higher in an effective ingredient holding medium having fluidity at a temperature near a human skin surface temperature, Wherein the percutaneous absorption medicinal composition is partially formulated in a crystalline form and the percutaneous absorption medicinal composition is formulated and applied to a skin such as a white rabbit which has been subjected to a shearing treatment with a hair clipper for 72 hours, The concentration of the active ingredient in plasma is at least 10 mg to 400 mg in terms of morphine based on the available amount of the active ingredient and at least 24 hours after the application of the preparation, And a transdermal absorption medicinal composition characterized by a conversion of 40 ng / ml.