Effective leader sequences needed for high expression of heterologous proteins

摘要

The present invention relates to a leader sequence for efficiently producing an exogenous protein and a method for efficiently producing an exogenous protein using the same. More specifically, the present invention relates to 75 leader sequences for expressing foreign proteins with high efficiency and expression vectors , A cell line transfected with the expression vector, a method for producing a recombinant foreign protein using the cell line, and a screening method capable of selecting an optimal leader sequence for high expression of an exogenous protein. The leader sequence, vector and cell line of the present invention can be useful for the production of various biopharmaceuticals.; Leader sequence, foreign protein, soluble receptor, cytokine, human monoclonal antibody, humanized monoclonal antibody