AIMP2 2 AIMP2 Moelecular Beacon for Dectecting Mutant of exon2-deleted AIMP2 and Method for Detecting Mutant of exon2-deleted AIMP2 Using thereof

摘要

More particularly, the present invention relates to a nucleic acid sequence which binds to the linkage region between exon 1 and exon 3 of AIMP2-DX2 and a complementary two-terminal sequence which forms a hairpin structure (AIMP2-DX2) in which a fluorescent substance is bound to one end of an oligonucleotide including a nucleic acid sequence having a fluorescent nucleotide sequence and a quencher (fluorescence quencher) is bonded to the other end, and a method for detecting AIMP2-DX2 using the same . According to the present invention, it is possible to accurately and quickly detect the exton 2 deletion mutation of AIMP2, which is considered to be an important marker for determining the tumorigenesis and cancer prognosis, It can be useful for prediction.