Lysimachia vulgaris var. davurica Ledeb. R.Kunth Pharmaceutical composition comprising extract of Lysimachia vulgaris var. davurica Ledeb. R.Kunth for Prevention or Treatment of bone diseases

摘要

The present invention relates to a pharmaceutical composition for the prevention and treatment of bone diseases containing an extract of Lysimachia vulgaris var. Davurica (Ledeb.) R. Kunth as an active ingredient, Inhibition of osteoclast differentiation and osteoclast-induced bone resorption by inhibiting the activation of ERK and p38 MAPK by osteoclast differentiation and reduction of expression of NFATc1 and c-Fos, and induction of bone loss by LPS By confirming that bone loss is suppressed and the number of osteoclasts is significantly reduced in an animal model, the berry extract can be usefully used as a composition for preventing and treating bone diseases.