首页> 外国专利> ANTIBODY OR ANTIGEN BINDING FRAGMENT BINDING TO CFP-10 OR AG85B FROM MYCOBACTERIA

ANTIBODY OR ANTIGEN BINDING FRAGMENT BINDING TO CFP-10 OR AG85B FROM MYCOBACTERIA

机译:与霉菌结合至CFP-10或AG85B的抗体或抗原结合片段

摘要

The present invention relates to an antigen binding fragment specifically binding to CFP-10 or Ag85B which are antibodies derived from mycobacteria; polynucleotide which codes the same; a recombinant vector comprising the polynucleotide; and a host cell comprising the recombinant vector. The CFP-10 or Ag85B which are antibodies derived from mycobacteria can be detected with high sensitivity by using the antigen binding fragment of the present invention. Thus, the antigen binding fragment can be developed into a kit which can rapidly and accurately detect mycobacteria. An antibody or an antigen binding fragment thereof comprises: a heavy chain variable region including an amino acid sequence represented by SEQ ID NO: 5; and a light chain variable including an amino acid sequence represented by SEQ ID NO: 6.
机译:本发明涉及与CFP-10或Ag85B特异性结合的抗原结合片段,CFP-10或Ag85B是衍生自分枝杆菌的抗体。编码相同的多核苷酸;包含多核苷酸的重组载体;包含重组载体的宿主细胞。通过使用本发明的抗原结合片段,可以高灵敏度检测作为分枝杆菌来源的抗体的CFP-10或Ag85B。因此,可以将抗原结合片段发展为可以快速且准确地检测分枝杆菌的试剂盒。抗体或其抗原结合片段包括:重链可变区,其包含由SEQ ID NO:5表示的氨基酸序列;和轻链变量,其包含由SEQ ID NO:6表示的氨基酸序列。

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