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- HYDROPHOBIC MODIFIED PRES-DERIVED PEPTIDES OF HEPATITIS B VIRUS HBV AND THEIR USE AS HBV AND HDV ENTRY INHIBITORS
- HYDROPHOBIC MODIFIED PRES-DERIVED PEPTIDES OF HEPATITIS B VIRUS HBV AND THEIR USE AS HBV AND HDV ENTRY INHIBITORS
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机译:-乙型肝炎病毒HBV疏水修饰的PRES衍生肽及其作为HBV和HDV进入抑制剂
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摘要
The present invention relates to a hydrophobically modified preS-derived peptide derived from the HBV preS common sequence, preferably the hepatitis B virus (HBV) wherein the N-terminus is acylated and the C-terminus is modified. This hydrophobic modified preS-derived peptide of HBV is not only a highly effective HBV intrusion inhibitor, but also an inhibitor of HBV and / or HDV infection, prevention of primary HBV and / or HDV infection, and (chronic) type B And / or hepatitis D. RTI ID = 0.0 The present invention also relates to pharmaceutical compositions and vaccine compositions comprising such hydrophobically modified preS-derived peptides of HBV.
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