METHOD FOR QUANTITATIVE EVALUATION OF FUNCTIONAL STATE OF ESSENTIAL BODY SYSTEMS

摘要

1. A method for quantifying the functional state of body systems, in which the process of developing sterile inflammation of a tissue site caused by ultraviolet (UV) radiation (UVI) of various spectral composition, intensity and dose, evaluated by the severity of hyperemia (erythema) of the UV irradiated area, is studied the fact that to measure the activity of the apoptosis system induced by UVI, the slope (k) and the point of intersection with the abscissa axis (maximum Non-Erythematic Dose - NED) are measured Depending on the degree of redness of the UV irradiated portion of the test body in various tissues (up to 48 h after UV irradiation) points vremeni.2. The method according to claim 1, characterized in that, in order to study the activity of drugs modulating apoptosis, compare the values of k and NED with systemic and / or local pharmacological effects modulating apoptosis activity and without them for fast and for delayed UV-B erythema. . The method according to claim 1, characterized in that, in order to study the functional state of the immune system, the kinetics of the development of redness caused by UV-C (250-280 nm) and UV-B (280-320 nm) irradiation with systemic and / or local pharmacological effects and without them. 4. The method according to claim 1, characterized in that, in order to study the intracellular repair systems, the degree of redness from the same doses of UV radiation obtained by UV irradiation of different intensities is compared. The method according to p. 1, characterized in that for measuring the trigger threshold of apoptosis induced by ultraviolet radiation, the kinetics of UV-B erythema obtained using microfraction irradiation is investigated in comparison with the kinetics of erythema obtained with p