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Compositions to reduce sensations caused by TRPA1 and TRPV1 receptors

机译:减少TRPA1和TRPV1受体引起的感觉的组合物

摘要

1. A hair dye composition comprising at least one of a TRPA1 receptor antagonist or a TRPV1 receptor antagonist and hydrogen peroxide. A hair coloring composition according to claim 1, characterized in that the TRPA1 antagonist is at least one of cinnamon bark oil; phloretin; γ-dodecalactone; vanillic acid; γ-methyl decalactone; trans, trans-2,4-nonadienal; 4-allyl-2,6-dimethoxyphenol; o-methoxycinnamic aldehyde; 4-methyl-2-phenyl-2-pentenal (a mixture of cis and trans); 2-methoxy-4-propyl-phenol; methyl 2-methoxy benzoate; δ-tetradecalactone; 1-methyl-2-pyrrolecarboxaldehyde; 3,3,5-trimethylcyclohexanol; N- (2-hydroxyethyl) lactamide; 2- (3-phenylpropyl) tetrahydrofuran; anisyl butyrate; methyl 4-phenylbutyrate; 3-heptyldihydro-5-methyl-2 (3H) -furanone; 3-acetylsulfanylhexyl acetate; 3-methyl-5-propyl-2-cyclohexen-1-one; isobornyl isobutyrate; bornyl valerate; citronell acetate; (2S, 5S, 6S) -6-hydroxy-dihydroteaspiran; or trans-2-hexenal. 3. A hair dye composition according to claim 1, characterized in that the TRPA1 antagonist is present in an amount of from about 0.0001% to about 0.50% by weight of the hair dye composition. A hair coloring composition according to claim 1, characterized in that the TRPV1 antagonist is at least one of (-) - bornyl acetate; hydroxycytronellal; apritone; methyl N, N-dimethylanthranilate; 2-ethoxy-3-ethylpyrazine; L-piperitone; isobornyl isobutyrate; 4-acetoxy-2,5-dimethyl-3 (2H) -furanone; tripropylamine; dihydrojasmon; 1-methyl-2-pyrrolecarboxaldehyde; 3-octyl acetate; 2-methylbutyl isovalerate; jasminone; piperonyl isobutyrate; phenoxyethyl propionate; vanillin propylene glycol acetate; octenylcyclopentanone; butyl isobutyrate; guaiac oil; or tetrahydro-4-me
机译:1.一种染发剂组合物,其包含TRPA1受体拮抗剂或TRPV1受体拮抗剂和过氧化氢中的至少一种。 2.根据权利要求1所述的染发组合物,其特征在于,所述TRPA1拮抗剂是肉桂皮油中的至少一种。芦丁γ-十二内酯;香草酸γ-甲基十氢内酯;反式,反式-2,4-壬二烯; 4-烯丙基-2,6-二甲氧基苯酚;邻甲氧基肉桂醛; 4-甲基-2-苯基-2-戊烯醛(顺式和反式的混合物); 2-甲氧基-4-丙基苯酚; 2-甲氧基苯甲酸甲酯; δ-十四内酯; 1-甲基-2-吡咯甲醛; 3,3,5-三甲基环己醇; N-(2-羟乙基)乳糖酰胺; 2-(3-苯丙基)四氢呋喃;丁酸茴香醚; 4-苯基丁酸甲酯; 3-庚基二氢-5-甲基-2(3H)-呋喃酮; 3-乙酰基硫基己基乙酸酯; 3-甲基-5-丙基-2-环己烯-1-酮;异丁酸异冰片酯;戊酸冰片;醋酸香茅酯(2S,5S,6S)-6-羟基-二氢硬脂酰胺;或trans-2-hexenal。 3.根据权利要求1的染发剂组合物,其特征在于TRPA1拮抗剂的存在量为染发剂组合物重量的约0.0001%至约0.50%。 2.根据权利要求1所述的染发组合物,其特征在于,所述TRPV1拮抗剂是(-)-乙酸冰片酯中的至少一种。羟基胞嘧啶丙酮N,N-二甲基邻氨基苯甲酸甲酯; 2-乙氧基-3-乙基吡嗪; L-哌啶酮;异丁酸异冰片酯; 4-乙酰氧基-2,5-二甲基-3(2H)-呋喃酮;三丙胺二氢茉莉1-甲基-2-吡咯甲醛;乙酸3-辛酯;异戊酸2-甲基丁酯;茉莉花异丁酸胡椒基酯;丙氧基苯氧乙酯香兰素丙二醇乙酸酯;辛烯基环戊酮;异丁酸丁酯;愈创木酚油或4-hydro-4-me

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