Pyrazolamine-pyrimidine derivatives as modulators enriched with leucine repeats of kinase 2 (LRRK2) for use in the treatment of Parkinson's disease

摘要

1. The compound of formula I: or a pharmaceutically acceptable salt thereof, wherein X is: —NR— or —O—, where R is hydrogen or C 1-6 alkyl; R 1 is: C 1-6 alkyl; Alkylene; Alkynyl; halogen-C1-6alkyl; Alkoxy-C1-6alkyl; hydroxy-C1-6alkyl; amino-C1-6alkyl; C1-6alkylsulfonyl-C1-6alkyl; C-cycloalkyl optionally substituted one or more times by C1-6alkyl; A cycloalkyl-C1-6alkyl, the C-cycloalkyl portion of which is optionally substituted one or more times by C1-6alkyl; heterocyclyl optionally substituted one or more times by an R group; or heterocyclyl-C1-6alkyl optionally substituted one or more times by an R group; or X and R together form a C1-6alkyl; Alkoxy-C1-6alkyl; Cycloalkyl optionally substituted one or more times by R; or a cycloalkyl-C1-6alkyl, the cycloalkyl part of which is possibly substituted one or more times by an R group; or R and R, together with the atoms to which they are attached, can form a three-six membered heterocyclic ring, possibly substituted one or more times by an R group; R is: C1-6alkyl; halogen atom; Salkoxy; cyano; Alkynyl; Alkylene; halogen-C1-6alkyl; halogen-alkoxy; Cycloalkyl optionally substituted one or more times by R; A cycloalkyl-C1-6alkyl, the cycloalkyl part of which is optionally substituted one or more times by an R group; -OR, where R is C1-6alkyl, Cycloalkyl optionally substituted one or more times by R, or Cycloalkyl-C1-6alkyl, the Cycloalkyl portion of which is optionally substituted one or more times by R; or —C (O) —R, where R is C1-6alkyl, Salkoxy, amino or heterocyclyl, optionally substituted one or more times with R; R3 represents: hydrogen; C1-6alkyl; halogen atom; cyano; halogen-C1-6alkyl; Alkylene; C-alkynyl; Salkoxy; Alkoxy-C1-6alkyl; hydroxy-C1-6alkyl;