首页> 外国专利> TREATMENT OF SIDE EFFECTS IN THE FORM OF MOTOR AND MOTOR DISORDERS RELATED TO THE TREATMENT OF PARKINSON'S DISEASE

TREATMENT OF SIDE EFFECTS IN THE FORM OF MOTOR AND MOTOR DISORDERS RELATED TO THE TREATMENT OF PARKINSON'S DISEASE

机译:帕金森氏病的治疗以及与电机疾病有关的各种形式的副作用的治疗

摘要

1. A method of treating a side effect of a motor disorder associated with administering levodopa to a patient having Parkinson's disease, the method comprising: administering to said patient in need of treatment a dose of eltoprazine or a pharmaceutically acceptable acid addition salt thereof to reduce said side effect as motor disorder, wherein said eltoprazine is administered at a dose of about 0.25 mg / day to about 25 mg / day. The method of claim 1, wherein said side effect of a motor disorder is dyskinesia. The method of claim 1, further comprising administering carbidopa. 4. The method of claim 1, wherein said eltoprazine is administered at a dose of from about 2.5 mg / day to about 10 mg / day. The method according to claim 4, wherein said eltoprazine is administered at a dose of about 2.5 mg / day. The method of claim 4, wherein said eltoprazine is administered at a dose of about 5.0 mg / day. The method of claim 4, wherein said eltoprazine is administered at a dose of about 7.5 mg / day. The method of claim 4, wherein said eltoprazine is administered at a dose of about 10 mg / day. The method of claim 1, wherein said patient is a human. A method according to claim 1 or 9, wherein said administration of eltoprazine does not reduce the effectiveness of said administration of levodopa. A method of treating Parkinson’s disease in a person in need thereof, the method comprising administering to said person a dose of levodopa and a dose of eltoprazine or a pharmaceutically acceptable acid addition salt thereof, wherein said eltoprazine is administered at a dose of from about 0.25 mg / day to about 25 mg / day 12. The method of claim 11, further comprising administering carbidopa. The method of claim 11, wherein said eltoprazine and said levodopa are both active in said
机译:1.一种治疗与帕金森氏病患者服用左旋多巴有关的运动障碍的副作用的方法,所述方法包括:向所述需要治疗的患者施用一定剂量的依托拉嗪或其药学上可接受的酸加成盐以降低作为运动障碍的所述副作用,其中所述依托拉嗪以约0.25mg /天至约25mg /天的剂量施用。 2.权利要求1的方法,其中所述运动障碍的副作用是运动障碍。 5.根据权利要求1所述的方法,进一步包括施用卡比多巴。 4.权利要求1的方法,其中所述依托拉嗪以约2.5mg /天至约10mg /天的剂量施用。 5.根据权利要求4的方法,其中所述依托拉嗪以约2.5mg /天的剂量施用。 5.权利要求4的方法,其中所述依托拉嗪以约5.0mg /天的剂量施用。 5.根据权利要求4所述的方法,其中所述依托拉嗪以约7.5mg /天的剂量施用。 5.如权利要求4所述的方法,其中所述依托拉嗪以约10mg /天的剂量施用。 2.根据权利要求1所述的方法,其中,所述患者是人类。 10.根据权利要求1或9所述的方法,其中所述依托拉嗪的施用不降低所述左旋多巴的施用的有效性。一种在有需要的人中治疗帕金森氏病的方法,该方法包括向所述人施用一定剂量的左旋多巴和一定剂量的依托拉嗪或其药学上可接受的酸加成盐,其中所述依托拉嗪以约0.25的剂量给予12.权利要求11的方法,进一步包括施用卡比多巴。 12.权利要求11的方法,其中所述依托拉嗪和所述左旋多巴在所述

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