COCHLEATES OBTAINED USING SOY PHOSPHATIDILSERIN

摘要

1. Cochleate containing: soy-based phospholipid, which contains about 40% -74% by weight of soybean phosphatidylserine, a multivalent cation and a biologically active agent. Cochleate according to claim 1, wherein the soy-based phospholipid is a mixture consisting of at least soy phosphatidylserine and phosphatidic acid. Cochleate according to claim 1 or 2, characterized in that the soy-based phospholipid contains about 45% -70% by weight of soy phosphatidylserine. Cochleate according to claim 3, characterized in that the soy-based phospholipid contains about 45% -55% by weight of soybean phosphatidylserine. Kohleat according to any one of paragraphs. 1, 2 or 4, characterized in that the biologically active agent is at least one agent selected from the group consisting of protein, small peptide, polynucleotide, aminoglycoside, antiviral agent, anesthetic, antibiotic, antifungal agent, antitumor agent, immunosuppressor steroidal anti-inflammatory agent, non-steroidal anti-inflammatory agent, tranquilizer, food supplement, herbal product, vitamin or vasodilator. 6. Cochleate under item 5, characterized in that the biologically active agent is at least one agent selected from the group consisting of aminoglycoside, amphotericin B, acyclovir, adriamycin, carbamazepine, curcumin, melphalan, nifedipine, indomethacin, naproxen, estrogen, testosterones, steroids, phenytoin, ergotamines, cannabinoids, rapamycin, propanidide, propofol, alfadione, echinomycin, miconazole nitrate, teniposide, taxane, paclitaxel and taxotere. 7. Kohleat according to any one of paragraphs. 1, 2, 4 or 6, characterized in that the multivalent cation is