RAMANOVSKY, INFRARED OR RAMANOVSK-INFRARED ANALYSIS OF THE STRUCTURE OF THE PROTEIN BLOOD PLASMA AND ITS RELATIONSHIP TO THE COGNITIVE DEVELOPMENT OF ALZHEIMER'S DISEASE

摘要

1. The method of vibrational spectroscopy to determine the protein structure in a blood sample associated with global cognitive impairment in Alzheimer's disease, comprising the following stages: a) recording the Raman spectrum of a previously obtained human blood sample; b) obtaining a Raman spectral value of at least one of the following areas Raman spectrum: R.1. area between 1600 and 1700 cm; R.2. area between 910 and 980 cm; R.3. the area between 730 and 760 cm; R.4. an area between 390 and 450 cm; where the mentioned spectral value is selected from the ratio of the Raman intensities between the ranges, the area of the mentioned spectral region and / or the frequency value; c) classification of the blood sample into one of the following classes: a blood sample containing a protein structure associated with non-cognitive impairment in Alzheimer's disease; II. a blood sample containing a protein structure associated with cognitive impairment in Alzheimer's disease; by comparing the Raman spectral value obtained in stage b with a reference spectral value that distinguishes between class I or II, or by multivariate analytical comparison of the Raman spectral value obtained on stage b, with reference spectral values of class I and class II.2. A vibrational spectroscopy method for determining a protein structure in a blood sample associated with global cognitive impairment in Alzheimer's disease, comprising the following steps: a) recording an infrared spectrum of a previously obtained human blood sample; b) obtaining an infrared spectral value of at least one of the following