METHOD OF PREDICTING RISK OF DEVELOPING PRIMARY OPEN ANGLE GLAUCOMA IN INDIVIDUALS DEPENDING ON PRESENCE/ABSENCE OF OTHER NON-COMMUNICABLE EYE DISEASES

摘要

FIELD: medicine.;SUBSTANCE: invention relates to medical diagnostics and concerns a method for prediction of risk of developing primary open-angle glaucoma depending on presence/absence of accompanying non-infectious pathology eyes in Russian individuals being natives of central black earth region of Russia. Method involves blood sampling and DNA recovery from peripheral venous blood with the following analysis of polymorphisms-VEGF-A-958C T, IGF-1 c.-1410T C, TGFβ-1 c.-1347T C, IGFR-1 g. 99181663C T. To predict a high risk of developing primary open-angle glaucoma in individuals with no concomitant pathology of non-eye if observing the allele T IGFR-1 or a combination of the allele with VEGF-A with alleles t IGFR-1 or a combination of the allele with VEGF-A with alleles t IGF-1 with alleles t TGFβ-1 or a combination of the allele t VEGF-A with alleles t IGF-1 with alleles with TGFβ-1. Predicted is low risk of POAG in without comorbidity eye genotype CC IGFR-1 and combination of genetic variants t VEGF-A and SS IGF-1. To predict a high risk of developing primary open-angle glaucoma among individuals with accompanying pathology eye if observing a combination of alleles with IGF-1 with with TGFβ-1 or a combination of the allele with VEGF-A with genotype VEHICLE IGF-1 with alleles with TGFβ-1.;EFFECT: predict low risk of this disease in individuals with accompanying pathology eye genotype TT TGFβ-1.;1 cl, 6 dwg