METHOD FOR PREDICTION OF RISK OF DEVELOPING PRIMARY OPEN-ANGLE GLAUCOMA STAGE III-IV

摘要

FIELD: medicine.;SUBSTANCE: invention relates to medical diagnostics and provides a method of predicting risk of primary open angle glaucoma stage III-IV, comprising isolating DNA from peripheral venous blood of individuals of Russian nationality who are natives of Central Black Soil Region of Russian Federation, analysis of polymorphisms of genes -308G / A TNFα,+ 250A/G Ltα, +36A/G TNFR1, thus making a forecast of increased risk of primary open angle glaucoma stage III-IV in case of these genetic variants allele -308G TNFα or genotype -308GG TNFα, or +250A allele Ltα or genotype +250A Ltα, or a combination of alleles -308G TNFα genotype +250AA Ltα, or combination of genotypes -308GG TNFα allele +36A TNFR1; and low risk of developing primary open angle glaucoma stage III-IV predict detection of a combination of allele -308A TNFα allele +36A TNFR1 and allele +250G Ltα or a combination of allele -308A TNFα c allele +36A TNFR1.;EFFECT: invention provides higher prediction accuracy.;1 cl, 3 dwg