METHOD FOR PREDICTION OF RISK OF DEVELOPING PRIMARY OPEN-ANGLE GLAUCOMA WITH INEFFECTIVE CONSERVATIVE THERAPY

摘要

FIELD: medicine.;SUBSTANCE: invention relates to medicine and concerns a method for predicting risk of primary open angle glaucoma (POAG) with ineffective conservative therapy in individuals of Russian nationality, who are natives of Central Black Soil Region of Russia. Method includes carrying out analysis of polymorphisms of TNFα (-308G/A TNFα) and predicting risk of POAG with ineffective conservative treatment, depending on options identified by locus of -308G/A TNFα and other predictors of development of disease according to equation: P=e^y/(1+e^y), (1) where "e" is a mathematical constant equal to 2.72; and "y" is calculated by logistic regression equation: y=15-0.099x₁+1.232x₂-0.099x₃+ 0.091x₄-1.292x₅-1.825x₆-0.911x₇, (2) where x₁ is age in years; x₂ is presence of cardiovascular disease: no - x₂ = 0, yes - x₂ = 1; x₃ is systolic blood pressure in mmHg; x₄ is diastolic blood pressure in mmHg; x₅ is presence of POAG with relatives: no - x₅ = 0, yes - x₅= 1; x₆ is presence of comorbidity eye: no - x₆ = 0, yes - x₆ = 1; x₇ is genetic variant locus -308G/A TNFα: for option AA- x₇ = 1 for variant AG- x₇ = 2, for option GG- x₇ = 3. If P is greater than 60 - predict risk of developing POAG with ineffective conservative therapy, if P is less than 40 - predict effectiveness of conservative treatment of POAG, if P is greater than 40 but less than 60 - more thorough dynamic follow up is necessary.;EFFECT: essence of method lies in that it includes isolation of DNA from peripheral venous blood.;1 cl, 2 dwg, 3 ex