AGONISTS OF PROTEIN TYROSINE PHOSPHATASE-1 CONTAINING HOMOLOGY-2 SRC DOMAIN, AND METHODS OF TREATING USING SAID AGONISTS

摘要

FIELD: pharmaceutics.;SUBSTANCE: in formula I R₁ and R₃ independently represent hydrogen, and R₂ represents , , , , or R₁ independently represents hydrogen, R₃ is methyl, and R₂ represents or or R₂ and R₃ independently represent hydrogen, and R₁ is . Invention also refers to pharmaceutical compositions containing said compound, a method for increasing Src homology-2 containing proteintyrosinephosphatase-1 (SHP-1) expression in a cell, method of treating diseases or pathological condition characterised by low expression SHP-1, and to use of said compounds for preparing a drug for treating diseases or pathological condition characterised by low expression of SHP-1.;EFFECT: disclosed are novel compounds of formula I, having Src homology-2 containing protein tyrosine phosphatase-1 (SHP-1) agonist activity.;11 cl, 6 tbl, 23 dwg, 2 ex