NANOPARTICLE BASED, TUMOUR-TARGETED DELIVERY OF MEDICINAL AGENTS

摘要

FIELD: medicine.;SUBSTANCE: group of inventions relates to aqueous tumour-targeted compositions of nanoparticles containing legumain-targeted lipid, containing a lipid component covalently bonded with binding legumain group, where binding legumain group includes legumain inhibitor type aza-Asn peptide with reactive part of presented formula (I): ; , ;as well as use thereof to treat expressing legumain tumour diseases.;EFFECT: group of inventions eliminated risks associated with targeting using ligands, while providing effective agents for tumour-specific drug delivery.;16 cl, 11 dwg, 1 tbl, 6 ex