3,3-DISUBSTITUTED-(8-AZABICYCLO3.2.1OCTA-8-YL)-5-(1H-PYRASOL-4-YL)-THIOPHEN-3-YL- METHANONE AND RELATED COMPOUNDS AND THEIR USE

摘要

FIELD: chemistry.;SUBSTANCE: invention relates to compounds of formula or its pharmaceutically acceptable salts thereof: ; ;wherein: -J¹ and -J³, taken together, form -CH₂CH₂-; -Q independently represents pyrid-2-yl and has n substitutes -R^F; or -Q independently represents pyrimidin-2-yl and has n substitutes -R^F; -n independently equal to 0, 1, 2 or 3; each -R^F independently represents -R^Z, -F, -Cl, -CF₃, -OH, -OR^Z, -OCF₃, -NH₂, -NHR^Z or -NR^Z ₂; each -R^Z, if present, independently represents an unsubstituted aliphatic saturated C_1-4alkyl; -Y independently represents -OH, -OR^YA, -F, -Cl or -CN; -R^YA independently represents saturated aliphatic C_1-6alkyl; -R^A1 independently represents -H or -R^AA; -R^A2 independently represents H or -R^AA; each -R^AA independently represents -R^AA1, -F, -Cl or -CN; each -R^AA1 represents saturated aliphatic C_1-4alkyl and possibly substituted with one or more groups -F; -R^B1 independently represents -H or -R^BB; -R^B2 independently represents H or -R^BB; each -R^BB independently represents -R^BB1, -F, -Cl or -CN; each -R^BB1 represents saturated aliphatic C_1-4 alkyl and possibly substituted with one or more groups -F; -R^N independently represents -H or -R^NN; and -R^NN is a saturated aliphatic C_1-4alkyl, which are inhibitors of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1).;EFFECT: novel compounds.;63 cl, 4 tbl, 47 ex