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COMPOSITION BASED ON NANOPARTICLES WITH IMPROVED PENETRATION THROUGH MUCOUS MEMBRANES
COMPOSITION BASED ON NANOPARTICLES WITH IMPROVED PENETRATION THROUGH MUCOUS MEMBRANES
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机译:通过纳米粒子改善了渗透性的基于纳米粒子的组合物
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摘要
FIELD: pharmaceutics.;SUBSTANCE: group of inventions refers to pharmaceutical industry, namely to hypotonic composition for fast and uniform distribution of therapeutic, prophylactic, diagnostic or nutriceutical mucosal surface agent containing particles, penetrating through mucus, which contain therapeutic, prophylactic, diagnostic or nutriceutic agent and polyalkylene oxide coating, improves penetration through mucus, which improves diffusion of particles through mucus, where the coating has coefficient of density [G]/[G*]3 , where l is density polyethylene glycol, which characterises the number of molecules of polyethylene glycol at 100 nm2 surface particles while G* is complete coating the surface of particles of which characterises the theoretical number of free molecules of polyethylene glycol, required for full coverage of 100 nm2 surface particles, as well as to a method of introducing one or more therapeutic, prophylactic and/or diagnostic agents to a human or animal with the help of said compositions.;EFFECT: group of inventions ensures manufacturing of particles, penetrating through mucus, completely protected against adsorption of mucus.;21 cl, 23 dwg, 8 tbl, 10 ex
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