METHOD OF PRODUCING COORDINATION COMPOUNDS OF OLIGOGALACTURONIC ACID WITH BIOGENIC METALS (II) AS DELIVERY SYSTEMS OF BIOGENIC METALS (II) AND SYSTEMS FOR REMOVING HEAVY METALS (II)

摘要

FIELD: medicine.;SUBSTANCE: invention relates to pharmacology, and describes a method of producing coordination compounds of oligogalacturonic acid with biogenic metals (II). Method involves production of pectin-containing preparation of oligogalacturonic acid with polymerisation degree equal to no less than 10, subjected to reaction with metal salt (II): copper, cobalt, iron, zinc, manganese, magnesium in aqueous medium at neutral pH, exposing reaction mixture at room temperature, neutralisation of formed acid, water flushing, centrifugation and drying precipitate. According to invention to 1 l of 5.0·10^-3 M aqueous solution of purified oligogalacturonic acid while stirring is added first 2 M aqueous solution of ammonia hydrate to pH 8, then 1 l of 4.5·10^-2 M aqueous solution of metal acetate (II); formed gel-like precipitate is treated with 96 % ethanol at volume ratio of 1:2, held for 2 hours.;EFFECT: invention ensures delivery of biogenic metals (II), as well as removal of heavy metal cations (II) from body.;1 cl, 8 tbl, 4 dwg, 6 ex