METHOD OF AMINOGLYCOSIDE ANTIBIOTICS IN SODIUM ALGINATE NANO-CAPSULES PRODUCING

摘要

FIELD: medicine.;SUBSTANCE: invention relates to nanotechnology and medicine. Described is method of aminoglycoside antibiotics in sodium alginate envelope nano-capsules producing. According to method according to invention aminoglycoside antibiotic is added in portions into sodium alginate suspension in benzene, containing E472c preparation as surfactant with mass ratio of aminoglycoside antibiotic: sodium alginate of 1:1 or 1:3. Mixture is stirred, then methyl ethyl ketone is added. Obtained suspension of nano-capsules is filtered, washed with methyl ethyl ketone and dried. Process is performed within 15 minutes.;EFFECT: method according to invention provides simplification and acceleration of nano-capsules producing process in sodium alginate and increases mass output.;1 cl, 1 dwg, 7 ex