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Specifically active molecules on the basis of sirna as well as application kit for their preparation and use
Specifically active molecules on the basis of sirna as well as application kit for their preparation and use
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机译:基于sirna的特异性活性分子以及用于其制备和使用的应用试剂盒
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摘要
Specifically active molecules on the basis of sirna to the biologically inactive transfection into a target cell, in order in this, after biological activation by means of binding to mrna and under formation of an risc " " - complex to inhibit the expression of genes, wherein the sirna for the purpose of their biological inactivation with at least one peptide is coupled via a linker, wherein the left as well as a peptide residue after the biological activation of the molecule on the sirna remains, characterized in that the sirna (2) via an amino - cn - linker (1) with cn = c3, c4, c5 and c6 to the at least one peptide (3) is coupled.
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