Three-dimensional in vitro - skin equivalent, comprising a biomatrix and cells embedded therein at least one first cell type, characterized in that the cells of the first cell type (a) at least a transgenic reporter gene, comprising at least one nucleotide sequence coding for a reporter protein under the control of a regulatory element which, by means of at least one is present in the cell type can be induced transcription factor and (b) have at least a transgenic receptor, wherein the protein coder end nucleotide sequence of the receptor gene receptors for growth factors or receptors for cytokines, namely for igf (insulin - like growth factor), of fgf - 2, of fgf - 7 (fgf: fibroblast growth factor), tnf - α (tumor necrosis factor α), tgf - α, tgf - β (transforming growth factor), egf (epidermal growth factor), vegf (vascular endothelial growth factor), pdgf - bb, pdgf - or pdgf - β (pdgf: platelet derived growth factor), or receptors of inborn immune system coded.
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