Measuring device and system for melting curve analysis of a dna microarrays, as well as the use of a fluorescence detector arrays for the analysis

摘要

It is a measuring device for simultaneous analysis of melting curves of dna - samples in dna microarrays with the aid of a fluorescence detector arrays shown. Exemplary embodiments show the monitoring of melting curves of dna - microarrays (dynamic fluorescence measurement) by means of silicon were - photo electrons holes ("silicone photomultiplier, sipm) or other photodetectors, such as, for example, pin - diodes (" positive intrinsic negative diode), avalanche photodiodes (apd) or photo electrons multiplying holes (pmt – photo multi pier tube). The dna - a microarray, together with a thin film heating element on a substrate made of plastic or glass, or is integrated in a microfluidic channel.