Matrix chromatography affinity a density of ligands reduced

摘要

The present invention relates to a matrix of affinity chromatography, in the form of a gel, comprising particles of polymer in which at least an oligosaccharide corresponding to an epitope of blood group and / or blood group b is grafted, via a spacer, characterized in that the density of oligosaccharides which is between 0,2 and 0,7 mg / ml of a matrix. The present invention also relates to the uses of this matrix for the preparation of concentrated immunoglobulin for therapeutic use.