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Immunogenic formulation containing recombinant live BCG that express antigens of metapneumovirus (HMPV), in a suspension prepared from a lyophilisate, without
Immunogenic formulation containing recombinant live BCG that express antigens of metapneumovirus (HMPV), in a suspension prepared from a lyophilisate, without
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机译:免疫原性制剂,由冻干液制备的悬浮液中含有表达间质肺病毒(HMPV)抗原的重组活卡介苗,而无
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摘要
The present invention relates to an immunogenic formulation to be used in mammals against human Metapneumovirus (hMPV), consisting of a lyophilisate of 1x10 9 ufc/ml of recombinant BCG that expresses the viral protein P of hMPV (of genogroups A1, A2, B1 and B2). The vaccine is derived from the full or partial product of the P gene of hMPV, capable of being used, stabilised and administered in solution without requiring adjuvants. The preparation can also contain combinations of the aforementioned formulations. The formulation is stabilised by means of lyophilisation (conservation range of between 4°C and 8°C) in order to be subsequently reconstituted in an adjuvant-free saline solution prior to use.
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