IMMUNOGENIC FORMULATION CONTAINING RECOMBINANT LIVE BCG THAT EXPRESS ANTIGENS OF METAPNEUMOVIRUS (HMPV), IN A SUSPENSION PREPARED FROM A LYOPHILISATE, WITHOUT REQUIRING AN ADJUVANT, SUITABLE FOR PHARMACEUTICAL USE

摘要

The present invention relates to an immunogenic formulation to be used inmammals againsthuman Metapneumovirus (hMPV), consisting of a lyophilisate of 1×10 9ufc/ml of recombinantBCG that expresses the viral protein P of hMPV (of genogroups A1, A2, B1 andB2). Thevaccine is derived from the full or partial product of the P gene of hMPV,capable of beingused, stabilised and administered in solution without requiring adjuvants. Thepreparation canalso contain combinations of the aforementioned formulations. The formulationis stabilised bymeans of lyophilisation (conservation range of between 4°C and8°C) in order to besubsequently reconstituted in an adjuvant-free saline solution prior to use.