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Use of cannabidiol in the treatment of intractable epilepsy

机译:大麻二酚在顽固性癫痫治疗中的应用

摘要

Cannabidiol for use in the treatment of epilepsy, wherein the epilepsy is a treatment-resistant epilepsy (TRE), and wherein the TRE is Tuberous Sclerosis complex (TSC), is provided. Preferably the TSC is characterised by both complex partial seizures and generalised seizures or primarily by complex partial seizures. Preferably the CBD is used in combination with one or more concomitant anti-epileptic drugs (AED) which may be selected from the group consisting of clobazam, levetiracetam, topiramate, stiripentol, phenobarbital, lacsamide, valproic acid, zonisamide, perampanel and fosphenytoin, wherein the dose of anti-epileptic drug/s that is/are used in combination with the CBD is reduced. Preferably the CBD is present as a highly purified extract which comprises at least 98% (w/w) CBD. Preferably the extract further comprises up to 1% CBDV (cannabidivarin) and less than 0.15% THC (tetrahydrocannabinol). Preferably the dose of CBD is from 5mg/kg/day to 25mg/kg/day.
机译:提供了用于治疗癫痫的卡那比二醇,其中所述癫痫是抗治疗性癫痫(TRE),并且其中所述TRE是结节性硬化复合物(TSC)。优选地,TSC的特征在于复杂的部分性发作和全身性发作,或主要特征在于复杂的部分性发作。优选地,所述CBD与一种或多种伴随的抗癫痫药(AED)组合使用,所述抗癫痫药可以选自:氯巴沙姆,左乙拉西坦,托吡酯,替替平醇,苯巴比妥,拉西酰胺,丙戊酸,唑尼沙胺,培南苯丙氨酸和磷苯妥英。与CBD组合使用的抗癫痫药的剂量减少了。优选地,CBD以包含至少98%(w / w)的CBD的高度纯化的提取物存在。优选地,提取物还包含至多1%的CBDV(大麻素)和小于0.15%的THC(四氢大麻酚)。优选地,CBD的剂量为5mg / kg /天至25mg / kg /天。

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