Bicyclo3.2.1octyl amide derivatives as allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5 or mGluR5) for the treatment of central nervous system (CNS) disorders

摘要

The present invention provides bicyclo[3.2.1]octyl amide derivatives of formula (I): wherein L, R 1 and R 2 are as defined herein, as allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5 or mGluR5) for the treatment of central nervous system (CNS) disorders, such as e.g. mood disorders, anxiety, schizophrenia, Alzheimer's disease, Parkinson's disease and multiple sclerosis.