Described herein are a method to identify relative cancer risk in a human subject,a method to differentiate human cancers, a method to diagnose cancer, and a method to treat cancer using a transcribed ultra-conserved region (T-UCR) expression profile consisting of at least one of uc.289, uc.285, uc.73, uc.291, uc.231, uc.233, uc.435, uc.183, uc.135, uc.349, uc.316, uc.122, uc.422, uc.144, uc.377, uc.262, uc.352, uc.192, uc.160, and combinations thereof; wherein the cancer is chronic lymphocytic leukemia (CLL).
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