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OPTIMIZED FLUOROCARBON EMULSIONS FOR BLOOD SUBSTITUTES AND OTHER THERAPEUTIC USES
OPTIMIZED FLUOROCARBON EMULSIONS FOR BLOOD SUBSTITUTES AND OTHER THERAPEUTIC USES
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机译:用于血液替代品和其他治疗用途的优化的氟碳乳液
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摘要
The present invention is directed to a stable fluorocarbon emulsion having a continuous aqueous phase and discontinuous fluorocarbon phase comprising two fluorocarbons and surprisingly demonstrates that perfluorodecyl bromide is as effective in stabilizing perfluorooctyl bromide emulsions of certain concentrations than much more highly concentrated perfluorooctyl bromide/perfluorodecyl bromide emulsions without the significant problems experienced in higher concentrated emulsions such as longer organ retention times, formation of PFDB crystals, larger emulsion particles, manufacturing problems and inability of repeat dosing inherent with higher concentrations of perfluorodecyl bromide.
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